RSAT peak-motifs: Efficient prediction of transcription factor motifs and binding sites from genome-wide sequencing peak sets

Morgane Thomas-Chollier, Matthieu Defrance, Olivier Sand, Carl Herrman, Denis Thieffry, van Helden Jacques

Abstract


Peak-motifs is a computational pipeline that discovers motifs in peak sequences, compares them with databases, exports putative binding sites for visualization in the UCSC genome browser and generates an extensive report suited for both naive and expert users. It relies on time- and memory-efficient algorithms enabling the treatment of several thousand peaks within minutes. Peak-motifs not only finds motifs associated the ChiPed factor, but usually further returns motifs potentially bound by cofactors.

Keywords


cis-regulatory element; ChIP-seq; motif discovery

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DOI: http://dx.doi.org/10.14806/ej.19.A.629

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