Describing the genes social networks relying on chromosome conformation capture data

Ivan Merelli, Pietro Liò, Luciano Milanesi

Abstract


The analysis of the chromosomal conformation in the nucleus is critical for understanding mechanisms that regulate genes colocalisation and coexpression. As for social networks that combine information about positions and activities of users, we show how it is possible, by using an R package developed for this purpose, to correlate the three-dimensional organisation of chromosome in the nucleus and gene activity during stem cell differentiation.


Keywords


chromosome conformation capture; NGS sequencing; neighbourhood graph

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DOI: http://dx.doi.org/10.14806/ej.19.B.735

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