SstmpDB: a database of single-spanning transmembrane proteins

Authors

  • Olga Bejleri <p>Department of Cell Biology and Biophysics, Faculty of Biology, Panepistimiopolis, University of Athens, Athens</p><p> </p>
  • Zoi Litou Department of Cell Biology and Biophysics, Faculty of Biology, Panepistimiopolis, University of Athens, Athens
  • Stavros Hamodrakas Department of Cell Biology and Biophysics, Faculty of Biology, Panepistimiopolis, University of Athens, Athens

DOI:

https://doi.org/10.14806/ej.19.B.732

Keywords:

database, single-spanning, transmembrane proteins, topology, protein function

Abstract

Membrane proteins represent ca. 20–30% of both eukaryotic and prokaryotic proteomes.  They play crucial roles in cell survival and cell communication, as they function as transporters, receptors, anchors and enzymes.  More than 30% of all prescribed drugs are targeting membrane proteins.  Transmembrane proteins are either single-spanning membrane proteins or multi-spanning proteins.  Single-spanning proteins can be classified into four types I, II, III and IV, depending on their topology and membrane targeting.  They are very important functionally, involved in the presentation of antigens to the immune system, they are calcium-dependent cell adhesion proteins, they play a role in septum formation and they have many more specific, crucial roles.

The purpose of this work was the construction of a database containing all single-spanning membrane proteins and their functional classification.  This database is available at  http://aias.biol.uoa.gr/sstmpdb

Author Biographies

  • Olga Bejleri, <p>Department of Cell Biology and Biophysics, Faculty of Biology, Panepistimiopolis, University of Athens, Athens</p><p> </p>
    MSc 'Bioinformatics' studentDepartment of Cell Biology and Biophysics, Faculty of Biology, Panepistimiopolis, Athens 157 84
  • Zoi Litou, Department of Cell Biology and Biophysics, Faculty of Biology, Panepistimiopolis, University of Athens, Athens
    Dr.Research AssistantDepartment of Cell Biology and Biophysics, Faculty of Biology, Panepistimiopolis, Athens 157 84
  • Stavros Hamodrakas, Department of Cell Biology and Biophysics, Faculty of Biology, Panepistimiopolis, University of Athens, Athens
    Professor and HeadDepartment of Cell Biology and Biophysics, Faculty of Biology, Panepistimiopolis, Athens 157 84

Downloads

Published

2013-10-14

Issue

Vol. 19: Supplement B

Section

Posters

License

Authors who publish with this journal agree to the following terms:
  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).