Describing the genes social networks relying on chromosome conformation capture data

Authors

  • Ivan Merelli Institute for Biomedical Technologies - National Research Council of Italy<br />
  • Pietro Liò University of Cambridge
  • Luciano Milanesi Institute for Biomedical Technologies - National Research Council of Italy

DOI:

https://doi.org/10.14806/ej.19.B.735

Keywords:

chromosome conformation capture, NGS sequencing, neighbourhood graph

Abstract

The analysis of the chromosomal conformation in the nucleus is critical for understanding mechanisms that regulate genes colocalisation and coexpression. As for social networks that combine information about positions and activities of users, we show how it is possible, by using an R package developed for this purpose, to correlate the three-dimensional organisation of chromosome in the nucleus and gene activity during stem cell differentiation.

Author Biographies

  • Ivan Merelli, Institute for Biomedical Technologies - National Research Council of Italy<br />
    Bioinformatics
  • Pietro Liò, University of Cambridge
    Computer Laboratory
  • Luciano Milanesi, Institute for Biomedical Technologies - National Research Council of Italy
    Bioinformatics

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Published

2013-10-14

Issue

Vol. 19: Supplement B

Section

Posters

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