Fingerprinting Breast Milk; insights into Milk Exosomics

Authors

  • Eleni Papakonstantinou Laboratory of Genetics, Department of Biotechnology, School of Applied Biology and Biotechnology, Agricultural University of Athens, 75 Iera Odos, 11855, Athens
  • Konstantina Dragoumani Laboratory of Genetics, Department of Biotechnology, School of Applied Biology and Biotechnology, Agricultural University of Athens, 75 Iera Odos, 11855 Athens
  • Antonia Mataragka Laboratory of Genetics, Department of Biotechnology, School of Applied Biology and Biotechnology, Agricultural University of Athens, 75 Iera Odos, 11855 Athens
  • Flora Bacopoulou Center for Adolescent Medicine and UNESCO Chair Adolescent Health Care, First Department of Pediatrics, "Agia Sophia" Children's Hospital, School of Medicine, National and Kapodistrian University of Athens, 115 27 Athens
  • Christos Yapijakis Center for Adolescent Medicine and UNESCO Chair Adolescent Health Care, First Department of Pediatrics, "Agia Sophia" Children's Hospital, School of Medicine, National and Kapodistrian University of Athens, 115 27 Athens
  • Nikolaos AA Balatsos Department of Biochemistry and Biotechnology, University of Thessaly, Biopolis, 415 00 Larissa
  • Katerina Pissaridi YIOTIS S.A., 128 - 130 Kifissou Avenue, 121 31, Athens
  • Dimitris Ladikos YIOTIS S.A., 128 - 130 Kifissou Avenue, 121 31, Athens
  • Aspasia Efthymiadou Institute of Technology of Agricultural Products, Hellenic Agricultural Organization "DEMETER", 14123 Lykovrisi
  • George Katsaros Institute of Technology of Agricultural Products, Hellenic Agricultural Organization "DEMETER", 14123 Lykovrisi
  • Evangelos Gikas Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, 15771 Athens
  • Pantelis Hatzis Institute for Fundamental Biomedical Research, Biomedical Sciences Research Center Alexander Fleming, Athens
  • Martina Samiotaki Institute for Bioinnovation, Biomedical Sciences Research Center "Alexander Fleming," 16672 Vari
  • Michalis Aivaliotis Basic and Translational Research Unit, Special Unit for Biomedical Research and Education, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki
  • Vasileios Megalooikonomou Multidimensional Data Analysis and Knowledge Management Laboratory, Computer Engineering and Informatics Department, School of Engineering, University of Patras, Patras
  • Antonis Giannakakis Laboratory of Gene Expression, Molecular Diagnostics and Modern Therapeutics, Department of Molecular Biology and Genetics, Democritus University of Thrace, 68100 Alexandroupolis
  • Costas Iliopoulos School of Informatics, Faculty of Natural & Mathematical Sciences, King's College London, WC2R 2LS, Bush House, Strand, London
  • Erik Bongcam-Rudloff Department of Animal Biosciences, Swedish University of Agricultural Sciences, Uppsala
  • Sofia Kossida IMGT®, the international ImMunoGenetics information system®, Laboratoire d'ImmunoGénétique Moléculaire LIGM, Institut de Génétique Humaine, (IGH), Centre National de la Recherche Scientifique (CNRS), Université de Montpellier (UM), Montpellier
  • Elias Eliopoulos Laboratory of Genetics, Department of Biotechnology, School of Applied Biology and Biotechnology, Agricultural University of Athens, 75 Iera Odos, 11855, Athens
  • George P Chrousos Center for Adolescent Medicine and UNESCO Chair Adolescent Health Care, First Department of Pediatrics, "Agia Sophia" Children's Hospital, School of Medicine, National and Kapodistrian University of Athens, 115 27 Athens
  • Dimitrios Vlachakis Laboratory of Genetics, Department of Biotechnology, School of Applied Biology and Biotechnology, Agricultural University of Athens, 75 Iera Odos, 11855, Athens

DOI:

https://doi.org/10.14806/ej.29.0.1048

Keywords:

breast milk, exosomes, omics technologies, infant health, infant nutrition

Abstract

Breast milk, often referred to as "liquid gold," is a complex biofluid that provides essential nutrients, immune factors, and developmental cues for newborns. Recent advancements in the field of exosome research have shed light on the critical role of exosomes in breast milk. Exosomes are nanosized vesicles that carry bioactive molecules, including proteins, lipids, nucleic acids, and miRNAs. These tiny messengers play a vital role in intercellular communication and are now being recognized as key players in infant health and development. This paper explores the emerging field of milk exosomics, emphasizing the potential of exosome fingerprinting to uncover valuable insights into the composition and function of breast milk. By deciphering the exosomal cargo, we can gain a deeper understanding of how breast milk influences neonatal health and may even pave the way for personalized nutrition strategies.

 

Author Biography

  • George P Chrousos, Center for Adolescent Medicine and UNESCO Chair Adolescent Health Care, First Department of Pediatrics, "Agia Sophia" Children's Hospital, School of Medicine, National and Kapodistrian University of Athens, 115 27 Athens
    shared corresponing authorhip with DV

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Published

2024-05-22

Issue

Vol. 29

Section

Research Papers

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