Deep insights into Mecp2-driven transcriptional (de)regulation at embryonic developmental stage through RNA-Seq data analysis

Abstract

Rett Syndrome (RTT, MIM 312750) is a progressive X-linked neurodevelopmental disorder due to mutation of the Mecp2 gene (encoding the transcription regulator methyl-CpG binding protein 2). To understand the biological mechanism behind transcriptional remodeling under the influence of Mecp2 knocking out, we need large-scale study of the transcriptional response of null cortical neurons before and after treatment with serotonin receptor stimulator.